MAPS-2 Study

The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke

IRAS 290474 CPMS 50728 Twitter @MAPS2trial

The aim is to test whether giving metoclopramide 10 mg three times a day for 14 days prevents pneumonia and death after acute stroke.

Please click RANDOMIZE to randomize a participant and enter/edit data. It will take you to the RedCap site.

Please click STUDY DETAILS for a protocol summary, the EOI form, the study team, and our newsletters.

If you have had green light to open the study you will have to authorize your local team on the Redcap Website. You will need the invitation email you have been sent with the temoprary password.

Please watch this video to show how to give metoclopramide/saline administration via the nasogastric tube.

We have 711 participants and 67 active centres plus 3 repatriation sites [26.3.24]

  1. Stoke-on-Trent 24.02.22 (Dr Anushka Warusevitane Ass PI Dr Sushanth Shankar) [133]
  2. Cambridge, Addenbrooks University Hospital 27.7.22 (Dr Kayvan Khandjooi) [29]
  3. Durham 19.5.22 (ANP Michelle Matthews) [26]
  4. Bury St Edmunds, West Suffolk Hopsital 3.5.22 (Dr Abdul Azim) [24]
  5. London, Northwick Park Hospital 28.7.22 (Dr Aravinth Sivagnanaratnam) [24]
  6. Crewe, Leighton Hospital 11.11.22 (Mrs Holly Maguire) [23]
  7. Bournemouth, Royal B. Hosptial 12.10.22 (Dr Katharine Fairbairn Ass PI Anthony Smith, Filipa Santana) [22]
  8. London, Royal London Hosptial (Dr Oliver Spooner) [20]
  9. Newcastle upon Tyne, Royal Victoria Infirmary 15.02.23 (Dr Michelle Davis) [21]
  10. Chester, Countess of Chester 12.07.22 (PI Prof Kausik Chatterjee, Ass PI Dr Pramodh Hettiarachchi) [19]
  11. Southhampton University Hospital 10.8.22 (Dr Shivaprasad Siddegowda, Ass |PI Dr Ahmed Elserafy) [19]
  12. Exeter Royal Devon and Exeter 9.6.22 (Prof Martin James Ass PI Dr Alison Griffin) [19]
  13. Nottingham, Queen’s Medical Centre 24.10.22 (Dr Senthil Raghnathan Ass Pi Dr Chaamanthi Menon) [18]
  14. Truro, Royal Cornwall Hosptial 21.8.22 (Dr Katja Adie) [18]
  15. Stockton-on-Tees, University Hosptial of North Tees 24.01.23 (Dr Sarah Whitehouse) [15]
  16. Aberdeen 4.4.22 (Dr German Guzman Gutierrez Ass PI Dr Hazel Thompson) [13]
  17. Leicester, University Hosptial 15.9.22 (Dr Kashif Musarrat) [13]
  18. Ulster, Northern Ireland SE HSCT 30.08.2023 (Dr Mark Bowman) [12]
  19. Leeds Teaching Hosptials 4.11.22 (Dr Vasileios Papavasileiou, AssPI Dr Rebecca Tremain) [12]
  20. Taunton, Musgrove Park Hospital 12.9.22 (Dr Babu Pusuluri) [12]
  21. Aberystwyth Bronglais Hospital 10.5.22 (Dr Syed Abid Raza) [10]
  22. Luton and Dunstable University Hosptial 7.12.22 (Dr Lakantha Alvis) [10]
  23. Birmingham, University Hosptial of Birmingham 7.11.22 (Dr Mark Wilmot) [10]
  24. London, Imperial College Charing Cross Hosptial 4.5.2023 (Dr Abid Malik) [10]
  25. Northampton General Hospital NHS Trust 26.09.22 (Dr Venkatesan Srinivasan) [9]
  26. Wolverhampton New Cross Hosptial 8.8.22 (Dr Nasar Ahmad) [9]
  27. Shrewsbury and Telford NHS Trust 1.11.2023 (Dr Indranil Mukhopadyay, Ass PI Sam Craik) [9]
  28. York 5.6.2023 (Dr Luke Bridge) [9]
  29. London, King’s College 3.5.2023 (Dr Rohan Pathansali) [8]
  30. Liverpool Aintree Liverpool Uinversity H hosptials NHSFT 1.09.2023 (Dr Thant Hlaing) [8]
  31. Bradford Teaching Hospital NHS FT 27.06.2023 (Dr Numan Khan) [8]
  32. Sunderland, Royal Sunderland Hospital 29.4.22 (Dr Naweed Sattar) [8]
  33. Carlisle North Cumbria Integrated Care NHSFT 6.3.23 (Dr Rachel Glover) [7]
  34. Middlesborough, James Cook Hosptial 27.6.22 (Mr Andrew Young) [7]
  35. Watford West Hertfordsire TH 27.2.22 (Dr Mohit Bhadari) [8]
  36. Dundee, Ninewells Hosptial 28.11.22 (Dr Matt Lambert) [6]
  37. Hairmyres, Lanarkshire 5.5.23 (Dr Philip Birschel) [5]
  38. Epsom and St Helier 27.06.2023 (Dr Puneet Kakar) [6]
  39. London St George’s12.04.2023 (Dr Youssif Abousleiman) [5]
  40. Carmarthen Glangwili GH 31.05.22 (Dr Pagdala Sridhar) [5]
  41. Swansea, Morriston Hosptial 11.5.22 (Dr Peter Slade) [5]
  42. Whiston St Helens and Knownsley 4.3.22 (Dr Sunanda Mavinamane) [5]
  43. Colchester Hosptital (5.9.23) (Dr Ramachandran Sivakumar) [5]
  44. Hull University Hosptial 27.09.23 (Dr Bernard Esisi, Dr Rayessa Rayessa) [4]
  45. Huddersfield, Calderdale and Huddersfield NHS FT 27.01.23 2022 (Dr Syed Ahmad) [4]
  46. Belfast, Royal Victoria Hospital 12.10.22 (Dr Patricia Fearon) [5]
  47. Milton Keynes University Hopstial NHS FT 1.9.22 (Dr Yousif Behnam) [4]
  48. London, UCLH 3.8.2023 (Dr Richard Perry) [4]
  49. Glasgow Royal Infirmary 12.9.22 (Prof Terry Quinn) [3]
  50. Glasgow, Monklands 27.06.22 (Dr Mark Barber) [3]
  51. Doncaster 23.05.2023 (Dr Dinesh Cahdha) [3]
  52. Derby, University Hosptials of Derby and Burton 13.01.23 (Dr Tim England, AssPI Dr Abdul Q. Aziz) [2]
  53. Llanelli Prince Philip 30.3.22 (Dr Senthil Kumar) [2]
  54. Sheffield Royal Hallamshire Hospital (DR Ali Ali) [2]
  55. Wansbeck Northumbria NHS FT 9.5.23 (Ms Anna Smith) [1]
  56. Liverpool Arrowe Park Wirral University Hospitals NHS FT 18.11.22 (Dr Ruth Davies) [1]
  57. Fife, Victoria Hosptial (11.09.2023) (Dr Vera Cvoro) [1]
  58. Antrim, Northern Healthcare Trust NI 23.05.2023 (Dr Murudappa Bhattad) [1]
  59. Norwich, Norfolk and Norwich University Hospitals NHS FT 21.6.22 (Dr Joyce Balami)
  60. Dorchester Dorset County H 23.03.23 (Dr Halald Proeschel)
  61. Gateshead Queen Elizabeth Hosptial 8.3.23 (Ms Bev McClelland)
  62. Southern Health and Social Care Trust NI 6.6.23 (Dr Michael McCormick)
  63. Manchester/Salford Northern Care Alliance FT 16.06.2023 (Prof Craig Smith)
  64. Enniskillen South West Acute Hosptital 07.09.2023 (Dr Breffni Keegan Ass PI Dr Brian Teehan)
  65. Chelmsford, Broomfield Hospital 28.09.23 (Dr Ramanathan Kirtivasan)
  66. Basildon University Hosptial 06.10.2023 (Dr Branimir Nevjada)
  67. Stockport, Stepping Hill Hosptial 15.11.23 (Dr Appukuttan Suman Ass PI Dr Bopage Kulathunga)
  68. Rotherham District General Hospital 22.02.2024 (DR Ruhail Mir) REPATRIATION SITE

Accociate PIS

  • Stoke: Sushanth Shankar 2022
  • Bournemouth: Anthony Smith (withdrawn Sep 2023), Filipa Santana Oct 2023
  • Exeter: Alison Griffin Nov 2022
  • Chester: Pramodh Hettiarachchi 2022
  • Nottingham: Chaamanthi Menon Jan 2023
  • Aberdeen: Hazel Thompson 2022
  • Leeds: Rebecca Tremain May 2023
  • Enniskillen: Brian Teehan Nov 2023
  • Stockport: Bopage Kulathunga Nov 2023
  • Shrewsbury: Sam Craik Nov 2023
  • Manchester: Crystal SingChiek Teoh (tbc) Omar Al Shujari Feb 2024
  • Derby: Abdul Quayoume Aziz Mar 2024

Sites closed

Sandwell Hospital 1.11.22 (Dr Sissi Ispoglou) Closed 1 Mar 2023